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Dapsone induced pancreatitis.Dapsone-induced acute pancreatitis |
Dapsone-Induced Isolated Acute Pancreatitis in a Child with Linear IgA Dermatitis | SpringerLink.
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J Pediatr Gastroenterol Nutr. Dapsone-induced acute pancreatitis. Ann Pharmacother. Article PubMed Google Scholar. Dapsone hypersensitivity syndrome in non-leprosy patients: A retrospective study of its incidence in a tertiary referral center in Taiwan.
J Dermatolog Treat. Agrawal S, Agarwalla A. Dapsone hypersensitivity syndrome: A clinico-epidemiological review. J Dermatol. PubMed Google Scholar. Download references. Alvaro Navarro-Mingorance, Antonio J. You can also search for this author in PubMed Google Scholar. Correspondence to Alvaro Navarro-Mingorance.
Reprints and Permissions. Navarro-Mingorance, A. Indian J Pediatr 81— Download citation. Received : 12 November Accepted : 08 August Published : 15 September Issue Date : July Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
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❿- A Case of Diabetic Ketoacidosis Caused by Dapsone-Induced Acute Pancreatitis.
Dapsone-induced acute pancreatitis - Publication types
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Objective: To report a case of acute pancreatitis associated with dapsone use. Case summary: An year-old white man was prescribed dapsone for dermatitis herpetiformis. Four weeks later, he developed acute abdominal pain requiring hospitalization. The patient had elevated serum amylase and lipase levels. Laboratory test results for other possible etiologies were negative.
His symptoms resolved when dapsone was discontinued. Dapsone was reintroduced for exacerbation of dermatitis herpetiformis 4 months later. The patient again had severe abdominal pain with high amylase and lipase levels.
Again, symptoms resolved following dapsone discontinuation. Discussion: Only 1 other case of pancreatitis associated with dapsone was found in a MEDLINE search of the literature June using the key terms dapsone and pancreatitis. An objective causality assessment revealed dapsone to be a probable cause of acute pancreatitis, based on the Naranjo probability scale. Drugs should always be considered as causative factors for pancreatitis in patients without known risk factors.
Dapsone is increasingly used as a second line of treatment of Pneumocystis carinii pneumonia PCP. The recognition of dapsone-induced pancreatitis is of particular importance in these patients. Conclusions: While dapsone is traditionally used for the treatment of leprosy and dermatitis herpetiformis, its use for PCP prophylaxis, malaria, brown recluse spider bites, and acne is not uncommon. Pancreatitis is an uncommon adverse effect of dapsone, and greater awareness of this association will prompt a high index of suspicion in an appropriate clinical setting.
Further reporting of cases and clinical research of drug-induced pancreatitis is indicated. Abstract Objective: To report a case of acute pancreatitis associated with dapsone use. Publication types Case Reports. Substances Cimetidine Dapsone Meperidine.
Dapsone, a commonly used drug, can cause various hypersensitivity reactions including AP collectively called “dapsone syndrome.” Here, we report dapsone-induced. Drug-induced pancreatitis can be caused by a wide array of medications. In fact, the diagnosis is likely commonly missed due to the difficulty. Drug-induced pancreatitis can be caused by a wide array of medications. In fact, the diagnosis is likely commonly missed due to the difficulty. Dapsone-Induced Isolated Acute Pancreatitis in a Child with Linear IgA Dermatitis. Alvaro Navarro-Mingorance & Antonio J. Dapsone, a commonly used drug, can cause various hypersensitivity reactions including AP collectively called "dapsone syndrome." Here, we report. Ann Pharmacother. Conclusions: While dapsone is traditionally used for the treatment of leprosy and dermatitis herpetiformis, its use for PCP prophylaxis, malaria, brown recluse spider bites, and acne is not uncommon. Correspondence to Alvaro Navarro-Mingorance.All rights reserved. Case Report. The Journal of Korean Diabetes ;17 4 Drug-induced pancreatitis accounts for 0. However, how dapsone causes pancreatitis remains unclear. A year-old man presented with a 2-week history of epigastric discomfort. He had taken dapsone for 2 months to treat psoriasis. Laboratory findings showed high blood glucose levels and metabolic acidosis; however, hemoglobin A1c was low. Abdominal computed tomography was indicative of pancreatitis. There was no causative history of pancreatitis and no other medication history except dapsone.
Thus, we reached a diagnosis of diabetic ketoacidosis DKA followed by dapsone-induced pancreatitis. The patient fasted and was treated with insulin administration and fluid hydration in accordance with treatment guidelines. After treatment, amylase and lipase decreased and symptoms subsided, but insulin injection was required to control blood glucose levels.
Drug-induced pancreatitis is a very rare adverse effect of dapsone. Only four cases of pancreatitis related to dapsone could be found in a PubMed search. Moreover, diabetes caused by dapsone-induced pancreatitis has not been reported previously. Here, we report a case of DKA caused by dapsoneinduced acute pancreatitis. Key Words: Dapsone , Diabetes , Pancreatitis.
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