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Z pack and prednisone
Combining an antibiotic with prednisone for short-term treatment of a condition is really a question of if the positives outweigh the risks. Azithromycin and prednisone are very commonly prescribed together for the short-term treatment of conditions like sinusitis and bronchitis since the benefit of therapy generally outweighs the risk of complications from the combination. In fact, one of the most commonly prescribed combinations of medications used for the short-term treatment of sinus infections is a Medrol Dose Pack which contains methylprednisolone, a similar steroid to prednisone and a Z-Pak azithromycin.
Several studies have published results showing preliminary positive benefits with short-term use of the combination:. The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection. However, for many individuals, a short-term course, at a relatively low dose of a steroid, is considered safe, with the benefits outweighing the risk. It is more commonly those that are taking steroids on a daily basis, or at high doses or both that we are more concerned about.
So, overall, there is no specific interaction between azithromycin and prednisone, and the drugs don't interfere with one another.
It's the conflict between immune suppression and treating an active infection that is the concern. As everyone's medical situation is different, I recommend talking to your doctor about what makes the most sense for you. Brian has been practicing pharmacy for over 11 years and has wide-ranging experiences in many different areas of the profession.
From retail, clinical and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Feel free to send him an email at Hello HelloPharmacist. You can also connect with Dr. Brian Staiger on LinkedIn. What medications can one take while on the medication warfarin for chest congestion and cough? Learn about 10 of these here. How to understand chronic pain What is behind vaccine hesitancy?
The amazing story of hepatitis C, from discovery to cure New directions in dementia research Can psychedelics rewire a depressed, anxious brain? Medical News Today. Health Conditions Discover Tools Connect. What is the difference between methylprednisolone and prednisone? Medically reviewed by Dena Westphalen, Pharm. Methylprednisolone vs. Share on Pinterest Methylprednisolone and prednisone reduce inflammation by suppressing the immune system. How do people take methylprednisolone and prednisone?
Share on Pinterest People can take methylprednisolone orally or as an injection. Image credit: Anonymous, Side effects. Share on Pinterest Prednisone can cause dizziness and nausea.
Image credit: nlm, Drug interactions. Share on Pinterest People with high blood pressure are more likely to experience complications from taking corticosteroids. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.
We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Share this article. Latest news Having a sense of purpose may help you live longer, research shows. Dementia vaccines: What are they, and when could they become available?
Exercising between 8—11 am may be best for cardiovascular health. Cancer: Intravenous delivery may improve nanoparticle vaccine efficacy.
Related Coverage. It's not just the unpleasant immediate side effects, such as jitteriness and difficulty sleeping; steroids can have serious side effects in the short term confusion and even psychosis are well known. In the long term, the list of possible side effects is very long, so the benefit must always be weighed against the possible harm. This is particularly the case in people at high risk for side effects, such as diabetics in whom sugar levels routinely go up when taking steroids or those with high blood pressure which often is exacerbated by steroid use.
Personally, I prefer to use nasal steroids in combination with antibiotics. They have many of the benefits of oral steroids with few of the side effects. Nasal steroids don't work as quickly as oral steroids, however.
In any case, I can't condone you not following your doctor's recommendations. I certainly do recommend that you have a discussion about the benefits versus the harms, and I'd also recommend that you ask about nasal steroids. Roach: I have read that atrial fibrillation gives you a greater chance of getting dementia. Do you agree?
❿Steroids and antibiotics prescribed together: New trend?.
Methylprednisolone vs. prednisone: What's the difference? - Description and Brand Names
View this study on Beta. Study Description. Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B.
The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B. Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success. The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will improve out come.
Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS.
LS will be used to evaluate lymphadenitis at each follow-up visit. The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids.
Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate. FDA Resources. Arms and Interventions. For this reason, doctors may prescribe methylprednisolone to someone with a risk of mental health conditions instead of prednisone to reduce the risk of psychosis. Due to these side effects, doctors may avoid prescribing these corticosteroids.
They may only recommend them if nonsteroidal anti-inflammatory drugs NSAIDs are not effective or if a person has severe inflammation. Corticosteroids can interact with many other medications, including some nutritional supplements and alternative medicines, such as herbal remedies. Before using corticosteroids, a person should tell their doctor about any other medications that they are taking.
Corticosteroids have a widespread effect on the body. As a result, they can cause complications, some of which are severe. Taking corticosteroids for more than a month, which doctors consider long-term use, increases the likelihood of adverse effects occurring. It is important to note that these drugs can reduce the activity of the immune system, which makes it harder for the body to fight infection. Complications are more likely to affect people who have or have had certain medical conditions, such as:.
Methylprednisolone and prednisone are corticosteroids that can have a significant impact on the body. They are effective medications for reducing inflammation. Both medications can produce a range of side effects and complications. Methylprednisolone is more potent than prednisone. Doctors can give methylprednisolone orally or through an injection, while prednisone is only available as an oral treatment. Methylprednisolone may, therefore, be more appropriate for people with digestive issues that stop them from taking or fully absorbing oral drugs.
Dear E. These studies have shown a speedier recovery in those taking the combination of steroids and antibiotics than in those who take antibiotics alone, and I suspect that is why your doctors, and those of your friends, have been prescribing them. However, there is a downside to steroids, as you note. It's not just the unpleasant immediate side effects, such as jitteriness and difficulty sleeping; steroids can have serious side effects in the short term confusion and even psychosis are well known.
In the long term, the list of possible side effects is very long, so the benefit must always be weighed against the possible harm.
This is particularly the case in people at high risk for side effects, such as diabetics in whom sugar levels routinely go up when taking steroids or those with high blood pressure which often is exacerbated by steroid use. Additionally, several studies have noted that individuals taking corticosteroids consistently, at high doses to treat certain inflammatory conditions such as rheumatoid arthritis, Crohn's, and ulcerative colitis are more at risk for certain infections due to the immunosuppression prednisone causes, namely: Common viral infections e.
Staphylococcus aureus Common fungal infections Candida species Having said all this, the dose of prednisone you are taking and how long you are taking it is highly relevant. Several studies have published results showing preliminary positive benefits with short-term use of the combination: Current evidence suggests that oral corticosteroids as an adjunctive therapy to oral antibiotics are effective for short-term relief of symptoms in acute sinusitis The point here is that, yes, there are concerns with taking a corticosteroid and how it can suppress the immune system, which increases the risk of infection.
Final Words Thanks for your question and please feel free to reach back out in the future! Was this article helpful? About the Pharmacist Dr. Brian Staiger, PharmD Dr. Still Confused? Ask the pharmacist a question here!
Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed. It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly.
Blood and urine tests may be needed to check for unwanted effects. If you or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor. This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention.
Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you take this medicine. Serious skin reactions, including Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms DRESS can occur with this medicine.
Check with your doctor right away if you or your child have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising or unusual tiredness or weakness while you are using this medicine.
Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin.
These could be symptoms of a serious liver problem. Call your child's doctor right away if your child feels irritable or vomits after feeding. These may be symptoms of a condition called infantile hypertrophic pyloric stenosis. Azithromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor.
Diarrhea medicines may make the diarrhea worse or make it last longer. If you or your child have any questions about this or if mild diarrhea continues or gets worse, check with your doctor. This medicine can cause changes in heart rhythms, including QT prolongation.
Methylprednisolone and prednisone are both corticosteroid medications. They have similar effects on the body but differ in their available forms and some of the side effects they cause. Both medications reduce inflammationand people use them to relieve the symptoms of many health conditions, such as rheumatoid arthritis RAlupusand eczema.
Methylprednisolone and prednisone are both corticosteroids. Corticosteroids can reduce inflammation in the body and relieve related symptoms, such as body pain, swelling, and stiffness. Corticosteroids reduce inflammation by suppressing the immune system.
They are a standard treatment for autoimmune conditions, which often cause inflammation in the body. Methylprednisolone and prednisone are both common medications that are similar in price. They can come in branded or generic forms. As with most drugs, the generic versions cost less but still comprise the same substances. Methylprednisolone is stronger than prednisone:. Prednisone is an oral medication that people take in the form of a tablet, liquid, or concentrated solution.
People will take between one and four doses a day depending on the medical condition and the effectiveness of the treatment. In many cases, a doctor will inject methylprednisolone into either the muscle or vein. However, for certain conditions, such as RA, they may sometimes inject methylprednisolone directly into a joint to reduce inflammation. Being injectable makes methylprednisolone easier than prednisone to provide in large doses. Both prednisone and methylprednisolone are very strong medications.
Doctors will try to use the lowest possible dosage that is effective, so they may increase or decrease the dosage during treatment. People who stop taking them too quickly may notice side effects, such as:. As methylprednisolone and prednisone are both very potent, they can cause a range of side effects, including:.
The side effects of prednisone can also include losing touch with reality. For this reason, doctors may prescribe methylprednisolone to someone with a risk of mental health conditions instead of prednisone to reduce the risk of psychosis. Due to these side effects, doctors may avoid prescribing these corticosteroids. They may only recommend them if nonsteroidal anti-inflammatory drugs NSAIDs are not effective or if a person has severe inflammation.
Corticosteroids can interact with many other medications, including some nutritional supplements and alternative medicines, such as herbal remedies. Before using corticosteroids, a person should tell their doctor about any other medications that they are taking. Corticosteroids have a widespread effect on the body. As a result, they can cause complications, some of which are severe. Taking corticosteroids for more than a month, which doctors consider long-term use, increases the likelihood of adverse effects occurring.
It is important to note that these drugs can reduce the activity of the immune system, which makes it harder for the body to fight infection. Complications are more likely to affect people who have or have had certain medical conditions, such as:. Methylprednisolone and prednisone are corticosteroids that can have a significant impact on the body.
They are effective medications for reducing inflammation. Both medications can produce a range of side effects and complications. Methylprednisolone is more potent than prednisone. Doctors can give methylprednisolone orally or through an injection, while prednisone is only available as an oral treatment.
Methylprednisolone may, therefore, be more appropriate for people with digestive issues that stop them from taking or fully absorbing oral drugs. A doctor will decide which medication is best in each situation. People should ensure that their doctor is aware of all their previous health conditions and current medications when discussing taking corticosteroids. Rheumatoid arthritis RA is an inflammatory disease that affects the joints and also produces symptoms throughout the body.
Find out more about how…. While researchers do not know exactly what causes rheumatoid arthritis RAthey do know that heredity plays a role. Learn more about RA and genetics…. Doctors use a combination of blood tests to help them diagnose rheumatoid arthritis. Learn more about these tests and what else the diagnostic process…. Rheumatoid arthritis causes pain, swelling, and inflammation in joints and can affect organs throughout the body. Find out more here.
The exact causes of rheumatoid arthritis are unclear, but researchers have identified several risk factors. Learn about 10 of these here. How to understand chronic pain What is behind vaccine hesitancy? The amazing story of hepatitis C, from discovery to cure New directions in dementia research Can psychedelics rewire a depressed, anxious brain?
Medical News Today. Health Conditions Discover Tools Connect. What is the difference between methylprednisolone and prednisone? Medically reviewed by Dena Westphalen, Pharm. Methylprednisolone vs. Share on Pinterest Methylprednisolone and prednisone reduce inflammation by suppressing the immune system. How do people take methylprednisolone and prednisone? Share on Pinterest People can take methylprednisolone orally or as an injection.
Image credit: Anonymous, Side effects. Share on Pinterest Prednisone can cause dizziness and nausea. Image credit: nlm, Drug interactions. Share on Pinterest People with high blood pressure are more likely to experience complications from taking corticosteroids.
How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles.
You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Share this article. Latest news Having a sense of purpose may help you live longer, research shows. Dementia vaccines: What are they, and when could they become available? Exercising between 8—11 am may be best for cardiovascular health. Cancer: Intravenous delivery may improve nanoparticle vaccine efficacy. Related Coverage. What are the symptoms of rheumatoid arthritis? Medically reviewed by Nancy Carteron, M.
Do people inherit rheumatoid arthritis? Medically reviewed by Stella Bard, MD. Blood tests for rheumatoid arthritis: Types and what to know. What is RA? Symptoms, treatments, causes, and everything else you need to know. What are 10 risk factors for rheumatoid arthritis?
Azithromycin Dose Pack has an average rating of out of 10 from a total of 65 ratings on localhost 48% of reviewers reported a positive effect, while 36%. The study hypothesis is that corticosteroids will improve out come. Ten patients with typical CSD will be treated with a 5-day oral course of prednisone (1 mg/. Is azithromycin a steroid? Dear Dr. Roach: In late spring of , I had a sinus infection and was prescribed both an antibiotic and prednisone. Among the agents used in Brazil to control infection by COVID, the corticosteroids and azithromycin stand out. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.Study record managers: refer to the Data Element Definitions if submitting registration or results information. Bartonella henselae is the etiologic agent of cat scratch disease CSD. In most CSD cases resolution occurs in 2 to 3 months although a prolonged course often occurs. Data on the efficacy of antibiotic therapy in CSD is limited.
Azithromycin has been shown to have a small favorable effect in a small comparative study and is commonly prescribed for CSD, however its overall effect is not satisfactory.
Corticosteroids may be effective in the treatment of CSD for the following reasons:. The total score will consist of the arithmetical summation of the 5 parameters. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : November 10, Last Update Posted : November 11, View this study on Beta. Study Description. Corticosteroids may be effective in the treatment of CSD for the following reasons: Many experts believe that host response is involved in the pathogenesis of CSD and is responsible for the clinical manifestations rather than the direct effect of B.
The absence of viable organisms in affected lymph nodes in the presence of positive PCR for B. Corticosteroids have been anecdotally reported to have been administered to patients with CSD, apparently with some success.
The purpose of this study is to evaluate the efficacy of corticosteroids in addition to azithromycin in CSD. The study hypothesis is that corticosteroids will improve out come. Patients will be under followed up for 3 months. Major outcome measures will include duration of symptoms and signs, with particular emphasis on affected lymph node size and duration using a specific scoring system lymphadenitis score, LS. LS will be used to evaluate lymphadenitis at each follow-up visit.
The historical control group will be consisted of age, sex, and clinical manifestations-matched CSD patients who were treated with azithromycin without corticosteroids. Drug Information available for: Azithromycin Azithromycin dihydrate Azithromycin monohydrate.
FDA Resources. Arms and Interventions. Intervention Details: Drug: prednison and azithromycin Patients with typical cat-scratch disease will be treated with a 5-day course of prednison and azithromycin. Outcome Measures. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.
Ability and willingness to comply with the protocol. Male and female patients aged years at the time of signing informed consent. Patients with clinical manifestations consistent with early typical cat scratch disease lymphadenitis before spontaneous improvement has been recorded and before development of suppuration. Known history of allergy, hypersensitivity, or any serious reaction to azithromycin, other macrolides or corticosteroids.
Patients for whom azithromycin or corticosteroids is contra-indicated. Current treatment with systemic corticosteroids. Patients with typical late cat scratch disease who has demonstrated constant improvement in the clinical manifestations of the involved lymph node. Atypical cat scratch disease e. Endocarditis due to Bartonella sp.. Diabetes mellitus. Peptic ulcer disease or history of upper GI bleeding.
History of inadequately treated tuberculosis or evidence of tuberculosis in the chest radiography. Schizoaffective disorder, anxiety or depression treated with antipsychiatric drugs, at present or in the past. Treatment with any investigational drug in any clinical trial within 30 days prior to administration of study medication. Contacts and Locations.
Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Cat-scratch Disease Bartonella Infections. Drug: prednison and azithromycin Drug: prednison, azithromycin Drug: prednison, Azenil. Phase 4. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Study Start Date :. Estimated Primary Completion Date :. November 10, Key Record Dates.
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