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In New Zealand adapalene is available in a cream or gel. The gel is suitable for most people but those with dry skin may prefer the cream. Discuss the best choice with your doctor. Read more about acne. Like all medicines, adapalene can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine. Looking for Where to get medical help A health professional or service Patient portals Newsletters View all.
Treatment for acne Belongs to a group of medicines known as retinoids. Redness or burning feeling on your skin Dry skin Skin peeling Flare up of acne. Keep moisturizing, and don't forget to use SPF sunscreen during the day to help protect your skin.
Both retinol and adapalene are retinoids, but only adapalene is FDA-approved to treat acne. Part of the Differin difference is a topical retinoid called adapalene.
During retinization —the adjustment period when your skin is getting used to Differin Gel — you might experience dryness, scaling, redness and burning or stinging. Plus, bonus: Some people never experience retinization at all! Help avoid irritation by steering clear of products with harsh chemicals like alpha hydroxy acid or glycolic acid, and other acne medications and treatments. According to the American Academy of Dermatology AAD , topical retinoids are recommended for mild and moderate acne over other products with salicylic acid.
But remember: You could start to see a reduction in acne after two weeks of treatment. Adapalene is designed to result in less redness and skin irritation than other prescription retinoids.
But first, retinization might cause some side effects that make your skin feel worse before it gets better. Retinoids work deep in your pores to clear your skin.
Retinization usually subsides after about four weeks. Adapalene adjusts the speed of skin cell turnover to help keep pores from clogging and target acne before it even starts. Learn more about how adapalene works. Treat your skin right. Make sure to moisturize, moisturize, moisturize! We know you do. Did you know you could buy them all in one Clear Skin Set? Wondering what the difference looks like in real life? Keep using Differin Gel every day, even after your skin looks clearer. Your long-term solution to clear and prevent acne.
Get prescription strength without a prescription. We put adapalene against other active ingredients on the market. See how it compares. Differin is different than what you're used to. Understand the process that makes it work. Knowledge, as they say, is power. Learn acne types, causes and best ways to deal. What should I expect?
❿- Adapalene (Topical Route) Proper Use - Mayo Clinic
Retinoids work deep in your pores to clear your skin. Retinization usually subsides after about four weeks. Adapalene adjusts the speed of skin cell turnover to help keep pores from clogging and target acne before it even starts.
Learn more about how adapalene works. Treat your skin right. Make sure to moisturize, moisturize, moisturize! We know you do. Did you know you could buy them all in one Clear Skin Set? Wondering what the difference looks like in real life? Keep using Differin Gel every day, even after your skin looks clearer.
Your long-term solution to clear and prevent acne. Get prescription strength without a prescription. We put adapalene against other active ingredients on the market. See how it compares. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people.
There is no specific information comparing use of adapalene in the elderly with use in other age groups. Older adults are not likely to develop acne. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription over-the-counter [OTC] medicine.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur.
Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.
To do so may cause irritation of the skin. Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying.
If the medicine accidently gets on these areas, wash with water at once. It works by unblocking the pores on the skin and in this way prevents blackheads and whiteheads. Adapalene also has anti-inflammatory properties, so it reduces the soreness and irritation of acne. In New Zealand adapalene is available in a cream or gel.
The gel is suitable for most people but those with dry skin may prefer the cream. Body as a whole. Immune system disorders. Skin and subcutaneous tissue disorders. These events often spontaneously resolve upon adaptation to therapy regimen. Reporting suspected adverse effects. Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product.
Healthcare professionals are asked to report any suspected adverse reactions at www. Differin Topical cream is intended for topical use only. If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur. Differin topical cream is not to be taken orally.
Unless the amount accidentally ingested is small, an appropriate method of gastric emptying should be considered. For information on the management of overdose, contact the Poisons Information Centre on Australia. Mechanism of action. Adapalene is a chemically stable compound with retinoid-like pharmacological activity. Biochemical and pharmacological profile studies have demonstrated that adapalene is a potent modulator of cellular differentiation, keratinisation and inflammatory processes all of which represent important features in the pathology of acne vulgaris.
Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but unlike tretinoin, does not bind to the cytosolic receptor protein.
Although the exact mode of action of adapalene is unknown, current evidence suggests that topical adapalene normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. Adapalene inhibits the chemotactic directional and chemokinetic random responses of human polymorphonuclear leucocytes in in vitro assay models.
It also inhibits the metabolism of arachidonic acid by lipoxidation, to inflammatory mediators. Clinical trials. The efficacy of Differin cream has been assessed in 2 randomised, double blind, parallel comparison clinical trials. In the first trial, subjects with acne vulgaris associated with at least 20 facial noninflammatory comedones and 10 inflammatory lesions were enrolled for treatment with Differin cream or the cream vehicle administered once daily.
In the second trial, subjects with acne vulgaris were enrolled for treatment with Differin cream or tretinoin cream 0. In clinical trials adapalene was seldom detected in plasma, and then only in trace amounts following chronic topical application with an analytical limit of quantification of 0.
After administration of 14 C-adapalene to rats, rabbits and dogs, radioactivity was distributed in several tissues, the highest levels being found in liver, spleen, adrenals and ovaries. Metabolism in animals is maintained by O-demethylation, hydroxylation and conjugation, and excretion is primarily by the biliary route.
In a human study performed using the gel formulation in which male volunteers followed a course of exaggerated topical application, 30 g a full tube was applied all over the body each day for 7 consecutive days, the resultant circulating plasma levels were below the limit of detection 0. There were low quantities of the parent substance in the faeces. In another study healthy volunteers used radiolabelled adapalene 0. The other 4 subjects received a single topical application of the radiolabelled product.
Levels of radioactivity in all plasma, urine, faeces and skin strip samples analysed were below the limits of reliable quantification, indicating that either very little or no radioactivity was absorbed through the skin.
A further study carried out to investigate the distribution of adapalene in the adipose tissue of women after repeated daily application of adapalene gel for 3 months, found that there was no evidence of circulating adapalene in the plasma limit of detection 0. On day 90, adapalene levels in the adipose tissue were not quantifiable in 5 of the 6 volunteers limit of detection 1 nanogram.
In the 6th volunteer the mean concentration at 3 sites was 1. These concentrations were no longer evident when re-evaluated at the same sites in this subject 1 month after the cessation of treatment.
Adapalene did not demonstrate mutagenic or clastogenic activity in in vitro tests with bacterial and mammalian cells and showed no clastogenic activity in mammalian cells in vitro and an in vitro test in mice. Lifetime studies with adapalene have been completed in mice at topical doses of 0. Phaeochromocytomas were observed in the adrenal medulla of male rats dosed at 1. This finding was not observed in female rats or in mice.
The relevance of the finding in male rats to the use of Differin Topical cream in acne vulgaris is not known. Carbomer P, PEG methyl glucose sesquistearate, glycerol, squalane, methyl hydroxybenzoate, propyl hydroxybenzoate, disodium edetate, methyl glucose sesquistearate, phenoxyethanol, cyclomethicone, sodium hydroxide, purified water.
Incompatibilities were either not assessed or not identified as part of the registration of this medicine. The expiry date can be found on the packaging. Avoid exposure to excessive heat. Replace cap tightly after use. Collapsible aluminium tube 3 g, 5 g, 30 g and 50 g coated internally with an epoxy-phenolic resin and fitted with a white polypropylene screw cap.
AUST R Not all pack sizes may be marketed. In Australia, any unused medicine or waste material should be disposed of by taking to your local pharmacy.
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Read more about acne. Like all medicines, adapalene can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine.
Looking for Where to get medical help A health professional or service Patient portals Newsletters View all. Keep using Differin Gel every day, even after your skin looks clearer.
Your long-term solution to clear and prevent acne. Get prescription strength without a prescription. We put adapalene against other active ingredients on the market. See how it compares. Differin is different than what you're used to. Understand the process that makes it work. Knowledge, as they say, is power. Learn acne types, causes and best ways to deal. What should I expect? Stick with it for 90 days to see the full effects—and finish the DifferinChallenge.
Week 1. Week 2. Retinoid Education During treatment with this medicine, avoid getting too much sun on treated areas and do not use sunlamps. Since your skin may be more prone to sunburn or skin irritation, use sunscreen or sunblocking lotions regularly with a sun protection factor SPF of 15 or more. Wear protective clothing against sun, wind, and cold weather. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission.
Mayo Clinic does not endorse any of the third party products and services advertised. A single copy of these materials may be reprinted for noncommercial personal use only. Drugs and Supplements Adapalene Topical Route. Tell your doctor if you are breast-feeding or planning to breast-feed. Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine. Ensure that the affected areas are dry before application. Ask your doctor or pharmacist if you are not sure how much to apply. They will tell you exactly how much to use for each application. Avoid the use of of oil-based makeups and creams. Cosmetic products with an abrasive, drying or peeling action may cause an extra irritant effect.
Pimples and spots will be reduced only after several application of this medicine. It may take weeks to notice an improvement and more improvement after further use. If it is almost time for your next dose, skip the dose you missed and use your next dose when you are meant to. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily.
Minimise exposure to sunlight and UV lamps. Protect your skin when you are in the sun, especially between 10 am and 3 pm. All medicines may have some unwanted side effects. Sometimes they are serious, but most of the time they are not. Your doctor has weighed the risks of using this medicine against the benefits they expect it will have for you.
Do not be alarmed by this list of possible side effects. You may not experience any of them. Tell your doctor as soon as possible if you notice any of the following and they worry you:. If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor. You may be asked to use the cream less often, or to stop using it until symptoms subside.
These are very serious side effects. You may need urgent medical attention or hospitalisation. Tell your doctor if you notice anything else that is making you feel unwell. Other side effects not listed above may occur in some patients. If you have queries about any aspect of your medicine, or any questions regarding the information in this leaflet, discuss them with your doctor or pharmacist.
Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
It is supplied in plastic tube with a plastic cap containing 3g, 5g, 30 g and 50g of cream or 5g, 30g and 50g of gel.
Excipients with known effect. Methyl hydroxybenzoate, propyl hydroxybenzoate. For the full list of excipients see Section 6.
Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes.
The affected areas should be dry before application. Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use. Cutaneous safety of Differin topical cream has been demonstrated in patients for up to 12 weeks of treatment. Since it is customary to alternate therapies in the treatment of acne vulgaris, it is recommended that the physician assess continued treatment of the patient with Differin topical cream after 3 months of use.
Not to be used in patients who are hypersensitive to the active substance or any of the excipients. For external use only. Differin Topical Cream should not come into contact with the eyes, lips, mouth and mucous membranes, angles of the nose or broken skin cuts and abrasions , sunburn or eczematous skin, nor should it be used in patients with severe acne involving large areas of the body.
If product enters the eye, wash immediately with warm water. Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body. If a reaction suggesting severe irritation occurs, discontinue use of the medication. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether.
If patients use cosmetics, these should be noncomedogenic and nonastringent. Only oil free moisturisers should be used to relieve dry facial skin.
Make Differin Gel a part of your daily skincare routine. And be sure to moisturize. Every Day. No excuses.
Be consistent: apply Differin Gel once a day, every day, at the same time of day. You may start to see some mild redness or irritation. Keep moisturizing, and don't forget to use SPF sunscreen during the day to help protect your skin.
Both retinol and adapalene are retinoids, but only adapalene is FDA-approved to treat acne. Part of the Differin difference is a topical retinoid called adapalene. During retinization —the adjustment period when your skin is getting used to Differin Gel — you might experience dryness, scaling, redness and burning or stinging.
Plus, bonus: Some people never experience retinization at all! Help avoid irritation by steering clear of products with harsh chemicals like alpha hydroxy acid or glycolic acid, and other acne medications and treatments. According to the American Academy of Dermatology AADtopical retinoids are recommended for mild and moderate acne over other products with salicylic acid. But remember: You could start to see a reduction in acne after two weeks of treatment. Adapalene is designed to result in less redness and skin irritation than other prescription retinoids.
But first, retinization might cause some side effects that make your skin feel worse before it gets better. Retinoids work deep in your pores to clear your skin. Retinization usually subsides after about four weeks. Adapalene adjusts the speed of skin cell turnover to help keep pores from clogging and target acne before it even starts.
Learn more about how adapalene works. Treat your skin right. Make sure to moisturize, moisturize, moisturize! We know you do. Did you know you could buy them all in one Clear Skin Set?
Wondering what the difference looks like in real life? Keep using Differin Gel every day, even after your skin looks clearer. Your long-term solution to clear and prevent acne. Get prescription strength without a prescription. We put adapalene against other active ingredients on the market. See how it compares. Differin is different than what you're used to. Understand the process that makes it work. Knowledge, as they say, is power. Learn acne types, causes and best ways to deal.
What should I expect? Stick with it for 90 days to see the full effects—and finish the DifferinChallenge. Week 1. Week 2. Retinoid Education Week 3. Wanna learn more? Find out from a dermatologist how retinoids are different than retinols — and how a retinoid like Differin Gel helps fight acne.
Wait… so my acne might get worse before it gets better? Week 4. Your skin is healing. Week 5. Weeks 6, 7, 8. Recognize these guys? Weeks 9, 10, Week You made it! So, what do I do now? Differin Gel adapalene 0. Shop Now. See Now. You May Also Like. We only send good stuff. Be the first to know about new products, discounts and skin health news.
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For best results, first wash skin with a mild (non-irritating), non-drying cleanser; apply a thin layer of Differin Gel to clean, dry skin (full face); and. Help avoid irritation by steering. It may take about 4 to 8 weeks before. Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas. PACKAGE LEAFLET: INFORMATION FOR THE USER. Differin % w/w Gel. Adapalene. Read all of this leaflet carefully before you start using this medicine because. In Australia, any unused medicine or waste material should be disposed of by taking to your local pharmacy. Older adults are not likely to develop acne. Inactive ingredients for the cream: carbomer P PEG methyl glucose sesquistearate glycerol squalane methyl hydroxybenzoate E propyl hydroxybenzoate E disodium edetate methyl glucose sesquistearate phenoxyethanol cyclomethicone sodium hydroxide purified water. Most reactions occurred within 1 month of the initiation of therapy and were generally observed to resolve with continued use of the product or temporary adjustment of the treatment schedule. Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment. Rub in gently and well. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.It does not contain all the available information. It does not use the place of talking to your doctor or pharmacist. All medicines have risks and benefits.
The product acts against the abnormal skin processes associated with acne. If it has expired or is damaged, return it to your pharmacist for disposal. Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. DIFFERIN gel contains methyl hydroxybenzoate E which may cause allergic reactions possibly delayed and propylene glycol which can cause skin irritation. Tell your doctor if you are pregnant or plan to become pregnant.
Your doctor can discuss with you the risks and benefits involved. Tell your doctor if you are breast-feeding or planning to breast-feed.
Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine. Ensure that the affected areas are dry before application.
Ask your doctor or pharmacist if you are not sure how much to apply. They will tell you exactly how much to use for each application. Avoid the use of of oil-based makeups and creams. Cosmetic products with an abrasive, drying or peeling action may cause an extra irritant effect. Pimples and spots will be reduced only after several application of this medicine. It may take weeks to notice an improvement and more improvement after further use. If it is almost time for your next dose, skip the dose you missed and use your next dose when you are meant to.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Otherwise, your doctor may think that it was not effective and change your treatment unnecessarily.
Minimise exposure to sunlight and UV lamps. Protect your skin when you are in the sun, especially between 10 am and 3 pm. All medicines may have some unwanted side effects. Sometimes they are serious, but most of the time they are not.
Your doctor has weighed the risks of using this medicine against the benefits they expect it will have for you. Do not be alarmed by this list of possible side effects. You may not experience any of them. Tell your doctor as soon as possible if you notice any of the following and they worry you:. If you experience sensitivity or irritation when applying this medicine, stop using it and tell your doctor.
You may be asked to use the cream less often, or to stop using it until symptoms subside. These are very serious side effects. You may need urgent medical attention or hospitalisation. Tell your doctor if you notice anything else that is making you feel unwell. Other side effects not listed above may occur in some patients.
If you have queries about any aspect of your medicine, or any questions regarding the information in this leaflet, discuss them with your doctor or pharmacist. Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines. It is supplied in plastic tube with a plastic cap containing 3g, 5g, 30 g and 50g of cream or 5g, 30g and 50g of gel. Excipients with known effect.
Methyl hydroxybenzoate, propyl hydroxybenzoate. For the full list of excipients see Section 6. Topical treatment of comedo, papular and pustular acne acne vulgaris of the face, chest or back. A thin film of Differin Topical cream should be applied to the affected areas once a day before bedtime and after washing avoiding the eyes, lips and mucous membranes.
The affected areas should be dry before application. Clinical improvement is expected to be evident in 4 to 8 weeks of treatment, with further improvement to be expected with continued use. Cutaneous safety of Differin topical cream has been demonstrated in patients for up to 12 weeks of treatment. Since it is customary to alternate therapies in the treatment of acne vulgaris, it is recommended that the physician assess continued treatment of the patient with Differin topical cream after 3 months of use.
Not to be used in patients who are hypersensitive to the active substance or any of the excipients. For external use only. Differin Topical Cream should not come into contact with the eyes, lips, mouth and mucous membranes, angles of the nose or broken skin cuts and abrasions , sunburn or eczematous skin, nor should it be used in patients with severe acne involving large areas of the body.
If product enters the eye, wash immediately with warm water. Because of a potential for increased irritation Differin Cream should not be used by patients with eczema, seborrhoeic dermatitis or severe acne involving large areas of the body. If a reaction suggesting severe irritation occurs, discontinue use of the medication. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether.
If patients use cosmetics, these should be noncomedogenic and nonastringent. Only oil free moisturisers should be used to relieve dry facial skin. Because Differin Topical cream may cause some irritation, it is possible that simultaneous use of abrasive cleansers, astringents or strong drying agents or irritant products may cause additive irritant effects. Animal studies on compounds with a similar mode of action to adapalene have suggested that these may enhance the development of skin cancers caused by UV light.
Adapalene is essentially stable to oxygen and light and is chemically nonreactive. Whilst short-term studies have shown no phototoxic to photoallergic potential of adapalene, small numbers of reactions consistent with phototoxicity were reported in clinical studies. The safety of using adapalene during long or repeated exposures to sunlight or UV radiation has not been established in animals or humans. Exposure to sunlight or UV irradiation including sunlamps should be avoided during treatment with adapalene.
Use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided. Efficacy and safety in the treatment of severe pustular or deep cystic acne acne conglobata have not been studied.
Differin Cream contains methyl hydroxybenzoate E and propyl hydroxybenzoate E that can cause allergic reactions can arise after the treatment is completed. Use in the elderly. No data available. Paediatric use. Safety and efficacy in children below the age of 12 years have not been studied. Effects on laboratory tests.
There are no known interactions with other medications which might be used topically and concurrently with Differin Topical Cream; however other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene. Exposure of adapalene to other topical antiacne drugs such as erythromycin, clindamycin phosphate or benzoyl peroxide does not produce any mutual degradation. Absorption of adapalene through human skin is low see Section 5. Differin topical cream has potential for local irritation and it is possible that concomitant use of peeling agents, astringents or irritant products may produce additive irritant effects.
Effects on fertility. In addition the incidences of various skeletal variations were increased at lower oral doses in rats. Because of the risk of teratogenicity shown in animals, and since there are no adequately controlled studies in pregnant women, adapalene should not be used by women who are pregnant or who plan to become pregnant during treatment. In case of unexpected pregnancy, treatment should be discontinued.
It is not known whether adapalene is excreted in human milk. Therefore, the preparation should be used with caution in nursing mothers, and only on areas away from the chest. Cautionary use of Differin during breast feeding should avoid contact exposure of the infant, application of Differin to the chest should be avoided when used during breast-feeding. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration.
A feeling of warmth, burning, pruritus, dryness, scaling or slight stinging may occur following application. Local adverse events may persist despite cessation of therapy. No systemic reactions have been attributed to the application of the cream to date. The allergic potential of adapalene has not been established. Side effects.
Redness, dry skin, burning sensation at the site of application and scaling. Skin irritation, pruritus and sunburn. Most reactions occurred within 1 month of the initiation of therapy and were generally observed to resolve with continued use of the product or temporary adjustment of the treatment schedule.
See Table 1. Postmarketing data. Differin Cream 0. The gel formulation was first marketed in France in September The postmarketing data detailed below refer to reports collected from the worldwide sales with the gel formulation.
Body as a whole.
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